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Medical and Research Library News - October 2021

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Training opportunities
Websites and reports on trending topics
Journal articles of note           

October 2021

Training opportunities

Note: The following webinars and online classes are not affiliated with DSHS or the DSHS Library. They are presented here as opportunities to learn more information of interest to public health personnel. All times listed are in Central Daylight Time.

October 7, 2021; 12-1:30 p.m. Responsive feeding and childhood obesity prevention: An equitable nurturing care perspective. Guiding the process of feeding infants and young children through responsive feeding principles is a central component of the responsive parenting and the UNICEF/WHO nurturing care frameworks. Responsive feeding addresses head on the ‘how to feed’ infants and young children following developmentally appropriate multidirectional interactions between infants and young children and their caregivers. Responsive feeding is vital for healthy growth, and social, psycho-emotional and cognitive development of infants and young children.
Presented by the Michael & Susan Dell Center for Healthy Living. https://register.gotowebinar.com/register/8925207990447772944

October 13, 2021; 11 a.m.-12 p.m. Improving hereditary cancer diagnostics using RNA sequencing: Lessons from a 43K patient study. There are technical and logistical limitations that hinder the identification of individuals at risk for hereditary cancer, resulting in many patients who undergo DNA genetic testing going undiagnosed. This webinar from the American Association for the Advancement of Science (AAAS) will review splicing data obtained from a cohort of over 43,000 individuals tested for cancer predisposition and demonstrate how RNA sequencing improves the diagnostic yield of genetic testing. A splicing profile performed in this clinical cohort demonstrated that over 6% of DNA variants identified result in abnormal splicing. It also led to the detection of novel deep-intronic mutations in patients who otherwise would have a negative or inconclusive result, representing approximately 1% of all pathogenic mutations identified in this study. https://view6.workcast.net/register?cpak=2665117831046224&referrer=Blast1&et_rid=198161687&et_cid=3937363

October 14, 2021; 2-3 p.m. Did you get the Mammo? In recognition of October's Breast Cancer Awareness month, the Health Resources & Services Administration (HRSA) is hosting a webinar to discuss breast cancer screening challenges and successes experienced during COVID-19 pandemic. The webinar will focus on the impact of the pandemic and the how we can recover and sustain screening rates moving forward. There will be a review of the UDS data from 2020 and the opportunity to ask questions of expert leaders in the field.  https://hrsa-gov.zoomgov.com/webinar/register/WN_9xsQdAfBSGiGTTPw1FN32g

October 21, 2021; 12-1 p.m. Texas Coronavirus Antibody REsponse Survey (CARES): Fall 2021 update. How bad is COVID-19 and the Delta Variant in Texas and how should schools respond? As Texas schools adapt for learning in the 2021-2022 school year, experts at the UTHealth School of Public Health will provide updated information on a statewide COVID-19 antibody study called Texas CARES. Presented by the Michael & Susan Dell Center for Healthy Living. https://sph.uth.edu/research/centers/dell/events/detail.htm?id=Texas-Coronavirus-Antibody-Response-Survey-Fall-2021-Update

October 25, 2021; 1-2 p.m. Community violence and mental health: Supporting patients and building resilience. Community violence is an urgent public health issue and an important social determinant of health. This session will focus on the effects of community violence on patient mental health, and strategies to support patients and build resilience. Subject matter experts will share personal stories, promising healthcare interventions, and tools for health center staff. Presented by the National Nurse-Led Care Consortium. https://nurseledcare.phmc.org/training/item/1152-community-violence-and-mental-health-supporting-patients-and-building-resilience.html

Websites and reports on trending topics

COVID-19 Vaccine Comparison - This past year, three COVID-19 vaccines produced by Pfizer-BioNTech, Moderna, and Janssen Biotech, Inc. were granted Emergency Use Authorization (EUA) by FDA. On Aug. 23, 2021, the FDA fully licensed the Pfizer-BioNTech product, marketed as Comirnaty, for persons aged 16 years and older. On Sept. 22, 2021, following recommendations from the Vaccines and Related Biological Products Advisory Committee, FDA amended the emergency use authorization for the Comirnaty COVID-19 vaccine to allow for a single booster dose to be administered at least six months after completion of the primary series for specific populations. On Sept. 23, 2021, CDC endorsed the Advisory Committee on Immunization Practices’ (ACIP) recommendations for a booster shot of the Comirnaty COVID-19 vaccine for certain populations and recommended a booster dose for those in high-risk occupational and institutional settings. A comparison of key details for each vaccine can be found in this issue brief from the Association of State and Territorial Health Officials (ASTHO). https://www.astho.org/COVID-19/Vaccine-Comparison/

MedlinePlus - Produced by the National Library of Medicine, this resource  has extensive information from the National Institutes of Health and other trusted sources on over 975 diseases and conditions. There are directories, a medical encyclopedia and a medical dictionary, health information in Spanish, extensive information on prescription and nonprescription drugs, health information from the media, and links to thousands of clinical trials. https://medlineplus.gov/

October is Breast Cancer Awareness Month - Each year in the United States, more than 250,000 women are diagnosed with breast cancer and 42,000 women die from the disease. This website from the CDC will help you recognize symptoms, identify risk factors and lower your risk

Journal articles of note

Mutnal MB, Johnson S, Mohamed N, et al. Surveillance genome sequencing reveal multiple SARS-CoV-2 variants circulating in the central Texas, USA with a predominance of Delta variant and review of vaccine breakthrough cases [published online ahead of print, 2021 Oct 1]. J Med Virol. 2021. doi:10.1002/jmv.27373
As surges in the COVID-19 pandemic have continued worldwide, SARS-CoV-2 has mutated, spawning several new variants, and impacting, to various degrees, transmission, disease severity, diagnostics, therapeutics, and natural and vaccine-induced immunity. Baylor Scott & White Health has implemented, along with laboratory diagnosis, SARS-CoV-2 sequencing to identify variants in its geographical service area. We analyzed virus sequencing results of specimens collected across Central Texas and found dramatic changes in variant distribution in the first half of 2021. The alpha variant (B 1.1.7) became predominant at week 13 and continued dominance until week 25. A growth rate of 1.20 (R2 = 0.92) for the first 15 weeks was noted and this growth gradually declined to -0.55 (R2 = 0.99) for the final 13 weeks. Currently, B.1.1.7 is being displaced with B.1.617.2 at 0.58 growth rate (R2 = 0.97). We also investigated vaccine breakthrough cases (VBCs) within our healthcare system and present clinical data on 28 symptomatic patients.

Neuman BW, Brashear WA, Brun M, et al. Case Report: Paucisymptomatic college-age population as a reservoir for potentially neutralization-resistant severe acute respiratory syndrome coronavirus 2 variants [published online ahead of print, 2021 Sep 20]. Am J Trop Med Hyg. 2021. doi:10.4269/ajtmh.21-0542
To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.

Salazar CI, Huang Y. The burden of opioid-related mortality in Texas, 1999 to 2019 [published online ahead of print, 2021 Sep 21]. Ann Epidemiol. 2021. doi:10.1016/j.annepidem.2021.09.004
Purpose: To examine and quantify the burden of opioid-related mortality utilizing a serial cross-sectional design of individuals 15 to 64 years of age whose death was related to opioid use from January 1, 1999, to January 31, 2019.
Methods: Data was obtained from the CDC WONDER Multiple Cause of Death Online Database, which captures mortality and population estimates across the United States stratified by geography, age, sex, race, and ethnicity. The burden of opioid-related deaths in Texas was evaluated as the proportion of all deaths attributable to this underlying cause of death over the study period and years of potential life lost (YPLL).
Results: Results revealed that between 1999 and 2019, 19,039 opioid-related deaths occurred among persons age 15 to 64, resulting in an increase of 402% over the study period (from 3.8 per 100,000 in 1999 to 8.2 per 100,000 in 2019). In 2019, the number of opioid-related deaths was highest among males (67.1%), non-Hispanic whites (76.0%), and adults aged 25-54 (74.1%). Overall, in Texas in 2019, opioid-related deaths resulted in 51,743 years of potential life lost (3.2 YPLL per 1000) most of which were among males (36,318 YPLL). Additionally, premature mortality due to opioids was highest among adults aged 25 to 34 years (5.1 YPLL per 1000) and those aged 35 to 44 years (3.8 YPLL per 1000).
Conclusions: We identified a steady yet significant rise in opioid-related mortality in Texas since 1999 and in particular among demographic groups considered at relatively high risk for midlife mortality. This study is also considered the first of its kind to quantify the burden of premature mortality related to opioid overdoses in Texas.

Sames WJ, Dunton RF, Bolling BG. A checklist of the mosquito species in 13 counties west of San Antonio, Texas. J Am Mosq Control Assoc. 2021;37(3):119-124. doi:10.2987/21-6997.1
The aim of this study was to consolidate mosquito information for 13 counties west of San Antonio, Bexar County, Texas, and to create a species checklist for future regional studies. The resulting checklist established a baseline for local mosquito-borne disease surveillance and can serve as a resource for public health officials. The 13 counties in this region were Bandera, Edwards, Kendall, Kerr, Kimble, Kinney, Maverick, Medina, Real, Sutton, Uvalde, Val Verde, and Zavala counties. To develop the checklist, county-level mosquito species data were extracted from 38 peer-reviewed publications and government documents, university reference collections, private collections, and the Texas Department of State Health Services' historical collection data. These data were combined with author field collections to create a comprehensive species list. Overall, 339 county-level records were documented through field studies with a total of 36 species representing 8 genera confirmed as being present in this region. An additional 14 species listed in historical surveillance records were not collected during this study.

Tadese BK, Nutt A, Chaudhary I, Offiong C, Darkoh C. Regional outbreak of multidrug-resistant Klebsiella pneumoniae carbapenemase-producing Pseudomonas Aeruginosa [published online ahead of print, 2021 Oct 1]. Infect Control Hosp Epidemiol. 2021;1-3. doi:10.1017/ice.2021.394
Klebsiella pneumoniae carbapenemase-producing P. aeruginosa (KPC-CRPA) are rare in the United States. An outbreak of KPC-CRPA was investigated in Texas using molecular and epidemiologic methods and 17 cases of KPC-CRPA were identified. The isolates were genetically related and harbored the emerging P. aeruginosa multilocus sequence type 235, the first in the United States.

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Last updated December 7, 2021