Data FAQs Immunization Investigation Reporting Resources
Disease Condition
Amebic Meningitis/Encephalitis
For more information about Primary Amebic Meningoencephalitis (PAM), please visit the Primary Amebic Meningoencephalitis webpage.
Organism
Granulomatous Amebic
Encephalitis (GAE) is caused by
Balamuthia mandrillaris or by Acanthamoeba
species, including A. culbertsoni, A. polyphaga, A. castellanii, A. astronyxis,
A. hatchetti, A. rhysodes, A. divionensis,
A. lugdunensis, A. lenticulata, and A. haelyi.
Other central nervous system (CNS) infections may be caused by other amebae
such as Sappinia species (including S. diploidea and S. pedata).
Transmission
Amebic
meningitis/encephalitis infections are not spread from person to person. The
amebae that cause amebic meningitis/encephalitis enter the body through
different routes, depending on the specific ameba:
Balamuthia
- Enters the body
when soil containing Balamuthia comes
in contact with skin wounds and cuts, or when dust containing Balamuthia is breathed in or gets in the
mouth. Once inside the body, the amebae can travel through the blood stream to
the brain, where they cause GAE. There are also a few reports of dogs that
might have become infected after swimming in ponds. Finally, there have been
reports of Balamuthia transmission to
organ transplant recipients from infected donors.
- There have been a few reports of Balamuthia transmission to organ transplant recipients from infected donors.
Acanthamoeba
- Enters the skin through a
cut or wound, or through the nostrils when breathed in.
- Once inside the body, the amebae travel through the bloodstream to other parts of the body, especially the lungs, brain, and spinal cord.
Sappinia
- May enter the body through the
nose or via cuts and bruises on the body.
- In the only known case, the patient
had signs of a sinus infection before developing symptoms of amebic
encephalitis.
Symptoms
The
symptoms of Granulomatous Amebic Encephalitis (GAE) vary depending on the infecting
ameba:
Balamuthia mandrillaris infection is very rare and serious, with a death rate of more than 89%. The disease might appear mild at first, but can become more severe over weeks to several months. Early diagnosis and treatment may increase the chances for survival.
Disease begins with a skin wound and can then travel to the brain causing GAE. Diagnosis of Balamuthia GAE can be difficult, but some early symptoms might include:
- Headaches
- Stiff neck or head and neck pain
with neck movement
- Sensitivity to light
- Nausea
- Vomiting
- Lethargy (tiredness)
- Low-grade fever
Other signs of Balamuthia GAE might include:
- Behavioral changes
- Seizures
- Weight loss
- Partial paralysis
- Difficulty speaking in full sentences
- Difficulty walking
Acanthamoeba species: This is a serious, most often deadly, infection of the brain and spinal cord. Symptoms progress over several weeks and death usually occurs.
- Headaches
- Stiff neck
- Nausea and Vomiting
- Tiredness
- Confusion
- Lack of attention
- Loss of balance and bodily control
- Seizures
- Hallucination
Sappinia species: There
is only one known case of Sappinia
encephalitis in a human. A scan of the one known infected patient’s brain revealed a 2-centimeter tumor-like mass on the back left section of the brain. Symptoms of Sappinia
infection may include:
- Headache
- Sensitivity to light
- Nausea or upset stomach
- Vomiting
- Blurry vision
- Loss of consciousness
Some groups
have a higher risk of infection or disease:
- Balamuthia
infection can occur in anyone.
- GAE caused by Acanthamoeba occurs more frequently in
people with compromised immune systems or those who are chronically ill.
- Amebic
encephalitis caused by Sappinia can infect anyone.
However, individuals with weakened immune systems and people who have contact with
animal feces are at a higher risk for infection.
Prevention
Currently,
there are no known ways to prevent infection with Balamuthia or Acanthamoeba.
Since persons with weakened immune systems are more susceptible to Acanthamoeba infection, they should
follow the advice of their treating physician carefully.
Recent Texas Trends
Other Amebic Meningitis and Encephalitis including
Granulomatous Amebic Encephalitis (GAE):
From 1972-2017, 13 other amebic meningitis/encephalitis
cases were reported to DSHS, nine caused by Balamuthia mandrillaris, three caused by Acanthamoeba species, and one by a Sappinia species. Texas’ 1998 Sappinia
pedata encephalitis case is the only known case of amebic encephalitis
caused by Sappinia, worldwide. In
2012, Texas confirmed a case of Acanthamoeba
healyi, a species not previously reported to cause human amebic
encephalitis.
Although GAE infections and other amebic meningitis and
encephalitis cases have always been reportable to Texas health departments as
exotic diseases, before 2012, PAM was the only amebic infection of the central
nervous system that was listed on the Texas Notifiable Conditions list.
